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Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
5 000 mg/kg bw
Quality of whole database:
There is one relevant, adequate and reliable study with structural analogue dodecyl methacrylate available (FHG, 1988) (Klimisch score = 1) The test was performed in accordance with generally accepted scientific standards and described in sufficient detail. Guideline study OECD 401, GLP.
This result is supported by three other acute oral toxicity studies with structuraly analogue long chain alkyl methacrylate esters (C12 -C22) with LD50 values above 5000 mg/kg. These results indicate a very low toxic potential of the long-chain alkyl methacrylate esters (C12 – C22).

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available
Quality of whole database:
Inhalation is no relevant route of exposure and testing by inhalation is not appropriate. Exposure of humans via inhalation is unlikely taking into account the low vapour pressure and the low possibility of exposure to aerosols, particles or droplets of an inhalable size.
Furthermore no reliable data are available on long-chain methacrylate esters (C12 – C22) for the inhalation route. However, data are available on the structural analogues substances: methyl-, ethyl- and n-butyl methacrylate. The respective LC50 values are in a range between 5000 and 11000 ppm indicating low inhalation toxicity.

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
3 000 mg/kg bw
Quality of whole database:
In a dermal acute toxicity study on isodecyl methacrylate (structurally related substance of tetradecyl methacrylate) with albino rabbits an
LD50 > 3000 mg/kg was determined. Reliable study according to generally accepted scientific standards and decribed in sufficient detail. This
experimentally observed result is supported by a dermal toxicity study with structural analogue dodecyl pentadecyl methacrylate where a LD50: > 5000 mg/kg, dermal, rabbit was observed (Rohm & Haas, 1975).

Additional information

Justification for classification or non-classification