Registration Dossier
Registration Dossier
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EC number: 932-231-6 | CAS number: 1335202-81-7
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
A series of studies were are available on the source analogue substance LAS that evaluate mutagenicity. A bacterial mutagenicity study (Ames test) was conducted on LAS at doses of up to 5000 ug/plate and was found to be negative for mutagenicity. Another study examined the potential of LAS to cause mutations in mammalian cells. In this study, Chinese Hamster Ovary (CHO) cells were exposed to concentrations of 0, 0.6, 1, 1.8, 3, and 6 ug/ml without S9, and 0, 6, 10, 18, 30, and 60 ug/ml with S9. There was no biologically significant increase in mutation frequency in the treated groups and therefore LAS is not mutagenic. This was confirmed in an in vivo study conducted on LAS using male and female NMRI strain mice exposed to a limit dose of 1122 mg/kg via gavage. No significant increases in the number of polychromatic erythrocytes with micronuclei were observed. These data demonstrate that LAS is negative for mutagenicity.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the data available on LAS, CaDDBS is not classified for mutagenicity.
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