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EC number: 932-231-6 | CAS number: 1335202-81-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Three separate repeated dose studies via oral exposure are reported. In the first, the resultant LOAEL and NOAEL values were 250 and 125 mg/kg bw/day, respectively. In the second, the resultant LOAEL and NOAEL values were 115 and 40 mg/kg bw/day, respectively. And in the third, the resultant LOAEL and NOAEL values were 145 and 85 mg/kg bw/day, respectively. This latter NOAEL represents the highest NOAEL below the lowest LOAEL in all of the studies and is therefore the appropriate NOAEL for use in the assessment.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 85 mg/kg bw/day
- Study duration:
- chronic
- Species:
- rat
Additional information
Three separate repeated dose studies via oral exposure are reported. In the first, male and female rats exposed to LAS via gavage daily for 28 days exhibited suppressed body weight gain, some serum biochemical effects, and some either decreased or increased organ weights relative to the controls in either the male or female high dose groups, but no mortalities or histopathological abnormalities. The resultant LOAEL and NOAEL values were 250 and 125 mg/kg bw/day, respectively.
In the second, male and female rats were exposed to LAS in the diet daily for 6 months. Diarrhea, suppressed growth, increased cecal weight, and degeneration of renal tubes characterized the highest dose group. Similar but less severe signs were seen in other doses with the exception of the lowest dose of 0.07%, which showed no adverse effects related to exposure to LAS. The resultant LOAEL and NOAEL values were 115 and 40 mg/kg bw/day, respectively.
And in the third, male and female rats were exposed to LAS in drinking water daily for 9 months. Again, body weight was suppressed in the highest dose group only. Significant decreases in transaminase activity and renal Na,K-ATPase was seen in the high dose group. The resultant LOAEL and NOAEL values were 145 and 85 mg/kg bw/day, respectively.
This latter NOAEL represents the highest NOAEL below the lowest LOAEL in all of the studies and is therefore the appropriate NOAEL for use in the assessment.
Justification for classification or non-classification
Based on the results of a series of repeated dose studies via either oral gavage or in the diet, the appropriate LOAEL and NOAEL values for use in the assessment are 145 and 85 mg/kg bw/day, respectively. These values do not meet the criteria for classification under either the DSD or CLP and therefore the substance is not classified.
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