Registration Dossier

Administrative data

Description of key information

Skin irritation/corrosion:  four reliable, guideline conform studies (OECD 404) are available with different commercial forms of the substance aluminium zirconium chloride hydroxide (powder, solution and concentrate solution). In all studies an absence of signs of skin irritation is reported.
Eye irritation/corrosion: four reliable, guideline conform studies (OECD 405) are available with different commercial forms of the substance aluminium zirconium chloride hydroxide (powder, solution and concentrate solution). Slight iridial inflammation and conjunctivitis were observed. The effects were not severe and reversible, so that the criteria for hazard classification are not met.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

Justification for selection of skin irritation / corrosion endpoint:
One of four key studies.

Justification for selection of eye irritation endpoint:
One of four key studies.

Justification for classification or non-classification

Skin irritation/corrosion: four reliable, guideline conform studies (OECD 404) are available with different commercial forms of the substance aluminium zirconium chloride hydroxide (powder, solution and concentrate solution). In all studies an absence of signs of skin irritation is reported.

Eye irritation/corrosion: four reliable, guideline conform studies (OECD 405) are available with different commercial forms of the substance aluminium zirconium chloride hydroxide (powder, solution and concentrate solution). Slight iridial inflammation and conjunctivitis were observed. The effects were not severe and reversible, so that the criteria for hazard classification are not met.

In conclusion, hazard classification for skin and/or eye irritation/corrosion is not required.