Registration Dossier

Administrative data

Description of key information

Acute oral toxicity: three reliable, guideline conform studies (OECD 401) are available with different commercial forms of the substance aluminium zirconium chloride hydroxide (powder and solution form). All studies indicate a low acute oral toxicity, with the LD50 larger than the limit dose, i.e. >  2000 mg/kg.
Acute inhalation toxicity: Based on uses and particle size consideration, the potential for inhalation exposure is low for aluminium zirconium chloride hydroxide (dermal and oral exposure more relevant).
Acute dermal toxicity: two reliable, guideline conform studies (OECD 402) are available with different commercial forms of the substance aluminium zirconium chloride hydroxide (solution form). Both studies indicate a low acute dermal toxicity, with the LD50 larger than the limit dose, i.e. > 2000 mg/kg.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Additional information

Justification for classification or non-classification

Acute oral toxicity: three reliable, guideline conform studies (OECD 401) are available with different commercial forms of the substance aluminium zirconium chloride hydroxide (powder and solution form). All studies indicate a low acute oral toxicity, with the LD50 larger than the limit dose, i.e. >  2000 mg/kg.

Acute inhalation toxicity: Based on uses and particle size consideration, the potential for inhalation exposure is low for aluminium zirconium chloride hydroxide (dermal and oral exposure more relevant).

Acute dermal toxicity: two reliable, guideline conform studies (OECD 402) are available with different commercial forms of the substance aluminium zirconium chloride hydroxide (solution form). Both studies indicate a low acute dermal toxicity, with the LD50 larger than the limit dose, i.e. > 2000 mg/kg.

Based on this data, classification for acute toxicity is not requried.