Registration Dossier
Registration Dossier
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EC number: 310-154-3 | CAS number: 121158-58-5
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The 14 and 21-day EC50 (immobilisation) values, based on nominal test concentrations, for the paternal Daphnia generation (P1) were calcualted to be 0.0082 and 0.0079 mg/L with 95% confidence limits of 0.0059-0.012 mg/L and 0.0055-0.011 mg/L respectively.
The 21-day EC50 (reproduction) value based on nominal test concentrations was calculated to be 0.0086 mg/L with 95% confidence limits of 0.0061-0.012 mg/L.
The "Lowest Observed Effect Concentration" was considered to be 0.012 mg/L on the basis that at this test concentration significantly fewer live your per adult (P<0.05) were produced when compared to the solvent control and that at this test concentration significant mortalities (immobilisation) were observed in the parental generation (P1).
The "No Observed Effect Concentration" was considered to be 0.0037 mg/L on the basis that at this test concentration there were no significant mortalities (immobilisation) observed in the parental generation (P1) and that there were no significant difference (P>= 0.05) between the solvent control and the 0.0037 mg/L test group in terms of numbers of live young produced per adult by day 21.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.004 mg/L
Additional information
In the key study (Sewell & McKenzie, 2005; SPL project number: 1666/028) for the effects on Daphnia reproduction, the study was conducted according to the OECD Guideline 211 (Daphnia Magna Reproduction Test) and EU Method C.20.
This study is presented as the key information as the reliability rating for this study is 1, according to the criteria of Klimisch, 1997.
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