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Toxicological information

Repeated dose toxicity: other routes

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Administrative data

Endpoint:
repeated dose toxicity: other route
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Remarks:
Review article with only results presented. Only Secondary Source reviewed.
Cross-reference
Reason / purpose:
reference to same study

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
An experimental study of the effects of rare metal on animal lungs.
Author:
Delanhant AB.
Year:
1955
Bibliographic source:
Arch Ind health 12: 116-120.
Reference Type:
publication
Title:
Biologic action of tungsten, carbide and carbon.
Author:
Schepers GWH.
Year:
1955
Bibliographic source:
AMA Arch Ind Health 12: 124-136.
Reference Type:
publication
Title:
The biological action of particulate tungsten metal.
Author:
Schepers GWH.
Year:
1955
Bibliographic source:
AMA Arch Ind Health 12: 124-136.
Reference Type:
review article or handbook
Title:
Occupational Respiratory Diseases - Carbide (Hard Metal Disease)
Author:
DHHS (NIOSH)
Year:
1986
Bibliographic source:
J. A. Merchant, Editor; Publication No. 86-102 : 438-444.

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data

Administration / exposure

Route of administration:
other: IT (Intratracheal)
Vehicle:
not specified
Details on exposure:
no data
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
no data
Frequency of treatment:
no data
Doses / concentrations
Remarks:
Doses / Concentrations:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
Experiments were undertaken to determine which of the metallic components in cemented tungsten might provoke lung lesions.

Examinations

Statistics:
no data

Results and discussion

Results of examinations

Clinical signs:
not specified
Mortality:
not specified
Body weight and weight changes:
not specified
Food consumption and compound intake (if feeding study):
not specified
Food efficiency:
not specified
Water consumption and compound intake (if drinking water study):
not specified
Ophthalmological findings:
not specified
Haematological findings:
not specified
Clinical biochemistry findings:
not specified
Urinalysis findings:
not specified
Behaviour (functional findings):
not specified
Organ weight findings including organ / body weight ratios:
not specified
Gross pathological findings:
no effects observed
Histopathological findings: non-neoplastic:
not specified
Histopathological findings: neoplastic:
not specified
Details on results:
Tungsten carbide produced little effect on guinea pig lung.

Effect levels

Dose descriptor:
NOEL
Effect level:
other: no data provided
Sex:
not specified
Basis for effect level:
other: Tungsten carbide produced little effect on guinea pig lung.

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

Mixtures of tungsten carbide and carbon were more harmful to guinea pig lung tissue than tungsten metal alone.

Applicant's summary and conclusion