Registration Dossier

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Additional information

For dicumyl peroxide no substance specific data on metabolism and kinetics are available. According to information from the German MAK Commission, organic peroxides are inactivated by glutathione (GSH) peroxidases and converted to less toxic metabolites (DFG, 1992). In the case of dicumyl peroxide this metabolism would result in 2-phenyl-2-propanol (CAS 617-94-7). This substance was investigated in the EU risk assessment for cumene (European Commission, 2001), as it is formed during metabolism after oral and inhalation exposure. 2-phenyl-2-propanol is eliminated from the body through excretion in the urine. Besides the unconjugated 2-phenyl-2-propanol the major metabolites found in urine were its glucuronide and/or sulphate conjugates. From a structural related substance benzoyl peroxide it is know that this organic peroxide penetrates unchanged through the stratum corneum or follicular openings of excised human skin and is converted metabolically to benzoic acid within the skin (OECD, 2004). Studies in rhesus monkey supported by information from humans indicate that there is no evidence of parental benzoyl peroxide in the systemic circulation. The renal clearance of the systemically absorbed metabolite is so rapid that it precludes passage through the liver - therefore, no systemic toxicity due to accumulation can be expected. It is expected that dicumyl peroxide will behave in a similar ways and that further investigations on distribution and metabolism are not regarded necessary for risk assessment.