Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 931-274-8 | CAS number: -
The study revealed no evidence for a respiratory sensitisation potential after repeated inhalative exposure to the test substance. This is not contradictive to the dose-related increase of specific test substance related IgG1 antibody counts observed, since only divalent reagins can mediate an asthmatic reaction. Nevertheless, the increase of specific IgG1 antibody titer give evidence that the aerosol was of respirability for the guinea pigs.
A study on Respiratory Sensitization was conducted, principally based on the method published by Karol et.al. (for instance Fundam. Appl. Toxicol. 5, 1985, 459). In this study groups of guinea pigs were exposed on 5 consecutive days for 3 hours daily to different concentrations of the test substance aerosol (0 (vehicle control), 3, 16, 49, and 261 mg/m³; MMAD approx. 1.5 µm, GSD approx. 1.4). After a treatment free period of at least 2 weeks a challenge experiment with exposure to the test substance aerosol (= hapten; 97 mg/m³; MMAD approx. 1.5, GSD approx. 1.5) was performed. After one further exposure free week a re-challenge with a synthetic protein-conjugate of the test substance (= antigen; 27 mg/m³; MMAD 3.7 µm, GSD 2.1; approx. 10 mol HDI isocyanurate/mol guinea pig albumin) was conducted. Lung function measurements were performed to investigate immediate or delayed effects after challenge. Additionally blood was sampled before challenge and investigated for specific IgG1-antibodies related to the substance.
All dose groups tolerated the induction exposure up to 261 mg/m³ without observable toxicological effects. No effect on body weight or body weight gain was observed compared to controls.
Lung function tests revealed no evidence of a lung sensitizing potential. No immediate or delayed hypersensitivity reactions could be detected neither after challenge with the test substance aerosol nor after conjugate challenge.
Animals of the 261 mg/m³ group showed slight increase in lung weights. Histopathology revealed in this group inflammatory changes in the lung; these were seen as causally related to the primary irritation potential of the substance. No evidence of recruitment of eosinophilic granulocytes in the airway walls was observed.
A concentration-related increase of specific test substance related IgG1 antibody counts demonstrated that the test substance aerosol was of adequate respirability for the animals.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again