Registration Dossier

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Significant methodological deficiencies: exposure to substantially saturated vapor atmosphere with unknown substance concentration, due to physical properties of the test substance this concentration is expected to be low, no other concentrations tested; review with compilation of data with insufficient documentation of test conditions and test results; data not acceptable for assessment

Data source

Reference
Reference Type:
review article or handbook
Title:
The place of the range finding test in the industrial toxicology laboratory
Author:
Smyth HF, Carpenter CP
Year:
1944
Bibliographic source:
J Ind Hyg Toxicol 26: 269-273

Materials and methods

Principles of method if other than guideline:
Method: other

Test material

Constituent 1
Chemical structure
Reference substance name:
Acetophenone
EC Number:
202-708-7
EC Name:
Acetophenone
Cas Number:
98-86-2
Molecular formula:
C8H8O
IUPAC Name:
1-phenylethan-1-one
Details on test material:
no data

Test animals

Species:
rat
Strain:
not specified
Sex:
male

Administration / exposure

Route of administration:
inhalation
Details on inhalation exposure:
Generation of satured vapour atmosphere by passing a flowing stream of air through a fritted disc bubbler at room temperature
Duration of exposure:
<= 8 h
Concentrations:
not measured: substantially saturated vapor atmosphere

Results and discussion

Mortality:
no deaths observed

Applicant's summary and conclusion