Registration Dossier

Administrative data

Endpoint:
toxicity to terrestrial arthropods: short-term
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: unsuitable test system

Data source

Reference
Reference Type:
publication
Title:
Insecticidal fumigants from defensive glands of insects - a fumigant test with adults of Drosophila melanogaster.
Author:
Dettner K, Fettköther R, Ansteeg O, Deml R, Liepert C, Petersen B, Haslinger E, and Francke W
Year:
1992
Bibliographic source:
J Appl Entomol 113, 128-137

Materials and methods

Principles of method if other than guideline:
The t(50%)-value (min) at which 50% of the 20 specimens of Drosophila melanogaster had died when the atmosphere of the test funnel was presaturated with substance vapour was determined. The test concentration was applied to filter paper and put in a sealed vial. After complete evaporation of the test chemical, 20 specimens of Drosophila were transferred to the vial. During the test the number of killed Drosophila was registered at least three times during the exposure period. The experiment was carried out at 24°C under constant light conditions.
GLP compliance:
no
Application method:
other: vapor

Test material

Constituent 1
Chemical structure
Reference substance name:
Acetophenone
EC Number:
202-708-7
EC Name:
Acetophenone
Cas Number:
98-86-2
Molecular formula:
C8H8O
IUPAC Name:
1-phenylethan-1-one

Test organisms

Test organisms (species):
Drosophila melanogaster
Animal group:
Diptera (fruit fly (small))

Study design

Study type:
laboratory study

Results and discussion

Effect concentrations
Duration:
1 min
Dose descriptor:
other: t50%
Effect conc.:
20 other: µM (concentration in the saturated atmosphere)
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality

Any other information on results incl. tables

The t(50%)-value (min) at which 50% of the 20 specimens of Drosophila melanogaster had died when the atmosphere of the test funnel was presaturated with substance vapour was determined. The test concentration was applied to filter paper and put in a sealed vial. After complete evaporation of the test chemical, 20 specimens of Drosophila were transferred to the vial. During the test the number of killed Drosophila was registered at least three times during the exposure period. The experiment was carried out at 24°C under constant light conditions.

Acetophenone was found to be a particularly effective fumigant: At a acetophenone concentration of 20 µM the t(50%) value was found to be ca. 1 min.

Applicant's summary and conclusion

Conclusions:
The t(50%)-value (min) at which 50% of the 20 specimens of Drosophila melanogaster had died when the atmosphere of the test funnel was presaturated with substance vapour was determined. Acetophenone was found to be a particularly effective fumigant: At a acetophenone concentration of 20 µM the t(50%) value was found to be ca. 1 min.