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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
vapour pressure
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
key study
Study period:
27 July 2009 - 23 September 2009
Reliability:
1 (reliable without restriction)

Data source

Reference
Title:
Unnamed
Year:
2009
Report date:
2009

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
yes
Remarks:
TGA sample pan was used to hold the sample horizontally
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
not specified
Type of method:
other: By calculation according OECD Test Guidance 104

Test material

Constituent 1
Chemical structure
Reference substance name:
4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile
EC Number:
700-455-1
Cas Number:
380843-75-4
Molecular formula:
C26H29Cl2N5O3
IUPAC Name:
4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile
Details on test material:
Equipment
Thermogravimetric Analyzer: TA Instrument Q 500 TGA
50ul Platinum sample pans: TA Instrument 952018.908

Temperature Calibration point Standards
Indium: Source: NIST; Certified Melting Temp.: 156.61ºC
Tin: Source: NIST Certified Melting Temp.: 231.95ºC

Vapour Pressure Reference Materials
n-Tricosane purity: 99.2%; Source: Chem Service; Lot: 309-98A
n-Hexacosane purity: 99.2%; Source: Chem Service; Lot: 209-53B
Benzophenone purity: 99.+%; Source: Acros Organics; Lot: AO240266

Results and discussion

Vapour pressureopen allclose all
Temp.:
ca. 20 °C
Remarks on result:
other: The vapour pressure could not be determined for technical reasons, as the sample was thermally unstable at temperatures required to determine an evaporation rate by isothermal thermogravimetry.
Temp.:
ca. 20 °C
Vapour pressure:
< 0 Pa
Remarks on result:
other: Using the calculation method described in OECD Test Guidance 104
Temp.:
ca. 20 °C
Vapour pressure:
< 0 Pa
Remarks on result:
other: Using the US EPA software MPBPWIN v. 1.43 (the modified Grain Method)

Applicant's summary and conclusion