Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-524-5 | CAS number: 142-16-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets general acceptable standards with limited data but sufficient to judge the results as reliable with restrictions to support REACH registration.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 949
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Similar to one day cuff method of Draize et al (J Pharmac exp Therap. 82-377, 1944)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Bis(2-ethylhexyl) maleate
- EC Number:
- 205-524-5
- EC Name:
- Bis(2-ethylhexyl) maleate
- Cas Number:
- 142-16-5
- Molecular formula:
- C20H36O4
- IUPAC Name:
- bis(2-ethylhexyl) but-2-enedioate
- Reference substance name:
- Dioctyl maleate
- EC Number:
- 220-835-6
- EC Name:
- Dioctyl maleate
- Cas Number:
- 2915-53-9
- Molecular formula:
- C20H36O4
- IUPAC Name:
- dioctyl but-2-enedioate
- Details on test material:
- no data
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Area of exposure: fur removed from entire truck area by clipping
% coverage
Type of wrap if used: impervious plastic film
Other:
Animals immobilized during exposure period - Duration of exposure:
- 24 hours
- Doses:
- not specified
- No. of animals per sex per dose:
- 4
- Control animals:
- other: no but a large number of other substances also tested which acted as reference
- Details on study design:
- Duration of observations period follwing administration: 14 days
- Statistics:
- No data
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 15 mL/kg bw
- Based on:
- test mat.
- Mortality:
- No data given on doses used or mortalities at respective dose levels. No available information on times of death, symptoms or findings during necropsy.
- Clinical signs:
- other: No information on symptoms
- Gross pathology:
- No information on findings
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- An LD50 of 15 ml/kg (14000 mg/kg) was determined.
- Executive summary:
In an acute dermal toxicity study in rabbits in which basic information was reported, an LD50 of 15 ml/kg was determined. Results indicate that the substance is not acutely toxic by dermal route.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
