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Diss Factsheets

Physical & Chemical properties

Partition coefficient

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Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
November 27, 1995 to Feb. 15, 1996
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: done under GLP and OECD method

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1997
Report date:
1997

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Directive 92/69/EEC, Method A8
GLP compliance:
yes
Partition coefficient type:
octanol-water

Test material

Constituent 1

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
ca. 0.2
Temp.:
23 °C
Remarks on result:
other: ± 0.06

Any other information on results incl. tables

IV-3-1 Preliminary tests

 

The preliminary test (saturation with each of the phases) leads to a value of log POwthat is close to -1.6, with the following as saturation concentrations:

 

--         2.8 mg/ml in the octanol;

--         100 mg/ml in the water (indications provided by the principal).

 

IV-3-2 Results

 

The measuring of the partition coefficient POwis carried out at 23ºC ± 1ºC. The result is expressed as a function of its base 10 logarithm.

 

The average of the values of log POwis:

 

0.20 ± 0.06

 

The interval ± 0.06 log unit is in accordance with the quality criteria of the Official Gazette of the European Communities no. L 383 A of 12/29/1992 (interval of ± 0.3 log units).

Applicant's summary and conclusion

Conclusions:
The partition coefficient has been determined to be log Pow 0.02.