1,1,3,3-tetramethyl-1,3-divinyldisiloxane

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

23 September 1987 - 7 October 1987

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1987

Report date:

1987

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: "OECD Short term and long term toxicology groups final report" adopted in May 1981

GLP compliance:

yes (incl. QA statement)

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

1,1,3,3-tetramethyl-1,3-divinyldisiloxane

EC Number:

220-099-6

EC Name:

1,1,3,3-tetramethyl-1,3-divinyldisiloxane

Cas Number:

2627-95-4

Molecular formula:

C8H18OSi2

IUPAC Name:

ethenyl[(ethenyldimethylsilyl)oxy]dimethylsilane

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Charles River Breeding Laboratories, Portage, Michigan
- Age at study initiation: 'young'
- Weight at study initiation: 237 +/- 18 grams
- Fasting period before study: ca. 18 hours prior to administration of test material
- Housing: All rats were housed individually in conventional design stainless steel, wire mesh bottom cages.
- Diet: Purina Rodent Chow, ad libitum
- Water: ad libitum
- Acclimation period: 7 days

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

5000 mg/kg

No. of animals per sex per dose:

5M, 5F

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days

- Frequency of observations and weighing: All animals were weighed 24 hours, 7 and 14 days after administration of the test material. The animals were observed frequently on the first day of dosing and twice a day thereafter, at least 4 hours apart during weekdays. Individual observations for mortalities and behaviour or other reactions were made for each animal.

- Necropsy of survivors performed: yes

- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: A complete gross pathologic examination was performed on all rats at the termination of the study.

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Mortality:

No deaths occurred.

Clinical signs:

other: No visible changes in animal behaviour or any signs of toxicity were observed.

Gross pathology:

Terminal sacrifice of the animals did not reveal any gross pathological alterations in the organs and tissues examined.

Other findings:

None reported.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

An LD50 value of >5000 mg/kg was reported in a study carried out according to current guideline and in compliance with GLP.