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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: oral

Currently viewing:

Administrative data

Endpoint:
repeated dose toxicity: oral
Remarks:
combined repeated dose and reproduction / developmental screening
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
RTECS Number: DE4550000
Year:
2012
Bibliographic source:
RTECS(Registry of Toxic Effects of Chemical Substances);JTSCDR Journal of Tox. Sci.(Japanese Soc. of Toxicological Sciences,4th Floor,Gakkai Center Bldg.,4-16,Yayoi 2-chome,Bunkyo-ku,Tokyo 113, Japan)V.1-1976-Vol.(issue)/page/year: 6,246,1981
Reference Type:
publication
Title:
Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan
Author:
JTSCDR Journal of Toxicological Sciences.
Year:
1981
Bibliographic source:
V.1- 1976- Volume(issue)/page/year: 6,246,1981

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
combined repeated dose and reproduction / developmental screening
GLP compliance:
not specified
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2-benzisothiazol-3(2H)-one 1,1-dioxide, sodium salt
EC Number:
204-886-1
EC Name:
1,2-benzisothiazol-3(2H)-one 1,1-dioxide, sodium salt
Cas Number:
128-44-9
Molecular formula:
C7H5NO3S.Na
IUPAC Name:
sodium 1,1,3-trioxo-2,3-dihydro-1H-1λ⁶,2-benzothiazol-2-ide
Details on test material:
- Name of test material (as cited in study report): 1,2-benzisothiazol-3(2H)-one 1,1-dioxide, sodium salt
- Substance type: organic
- Physical state:solid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Duration of treatment / exposure:
36 Weeks (continuous)

Results and discussion

Effect levels

Dose descriptor:
other: TDLo - Lowest published toxic dose
Effect level:
756 000 mg/kg bw/day (nominal)
Based on:
test mat.
Sex:
not specified

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

TOXIC EFFECTS :

Kidney, Ureter, Bladder - other changes in urine composition Kidney, Ureter, Bladder - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain.

Applicant's summary and conclusion

Executive summary:

Kidney/Ureter/Bladder - other changes in urine composition Kidney/Ureter/Bladder - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain was observed in the multiple dose toxicity study for this substance.