Registration Dossier
Registration Dossier
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EC number: 907-605-7 | CAS number: 68815-47-4
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Microorganism toxicity was assessed in a reliable activated sludge respiration inhibition study performed according to the new version of the OECD 209 guideline and compliant to GLP.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 335 mg/L
- EC10 or NOEC for microorganisms:
- 12 mg/L
Additional information
A new reliable (reliability category 1) study for the submission substance was performed according to OECD 209 (adopted 2010) and compliant to GLP. The mean inhibition of the respiration rates for the tested concentrations was 8.8% at 10 mg/L, 21% at 32 mg/L, 31% at 100 mg/L, 48% at 320 mg/L and 68% at 1000 mg/L compared to the control, i.e. a clear concentration-effect relationship on the inhibition of the respiration rate was determined.
Based on these results, the ECX values and their 95% confidence limits were calculated as follows:
EC10 12 mg/L, 95% confidence limits: 6.4 - 18 mg/L
EC20: 37 mg/L, 95% confidence limits: 25 - 51 mg/L
EC50: 335 mg/L, 95% confidence limits: 267 - 432 mg/L
EC80: >1000 mg/L
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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