Registration Dossier
Registration Dossier
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EC number: 500-151-7 | CAS number: 61791-12-6 1 - 6.5 moles ethoxylated
Endpoint summary
Administrative data
Description of key information
Hydrolysis
HYDROWIN v2.00 program of Estimation Programs Interface (2018) prediction model was used to predict the hydrolysis half-life of test chemical. The estimated half-life of test chemical was determined to be 1.707 yrs and 62.345 days at pH 7.0 and 8.0 (at 25ᵒC) respectively, indicating that it is not hydrolysable.
Additional information
Hydrolysis
Predicted data and various experimental studies of the test chemical were reviewed for the hydrolysis end point which are summarized as below:
In a prediction done using the HYDROWIN v2.00 program of Estimation Programs Interface (2018) prediction model was used to predict the hydrolysis half-life of test chemical. The estimated half-life of test chemical was determined to be 1.707 yrs and 62.345 days at pH 7.0 and 8.0 (at 25ᵒC) respectively, indicating that it is not hydrolysable.
In a supporting weight of evidence study from authoritative databases (2017) for the test chemical,the hydrolysis half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant of test chemical was determined to be 0.15 L/mol-sec with corresponding half-lives of 1.5 yrs and 55 days at pH 7 and 8, respectively.
For the test chemical, the hydrolysis half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical (HSDB, 2017). The second order hydrolysis rate constant of test chemical was determined to be 0.27 L/mol-sec with corresponding half-lives of 294 days and 29 days at pH 7 and 8, respectively.
On the basis of the above results for test chemical, it can be concluded that the hydrolysis half-life value of test chemical was evaluated to be 29 days to 1.707 yrs, indicating that the test chemical is not hydrolysable.
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