Registration Dossier

Administrative data

Description of key information

GTN is harmful.
Acute toxicity by oral was done on rats
Acute toxicity by dermal was done on rats
Acute toxicity by inhalation - study technically not feasible

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
853 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
discriminating conc.

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
Value:
9 560 mg/kg bw

Additional information

Undiluted nitroglycerin is a 'sensitive' high explosive and the danger of a major explosion of TNG vapors or mist in an inhalation study, with resulting major damage to personnel and facility, is too great to consider undertaking such a toxicological study

Justification for classification or non-classification