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Administrative data

Link to relevant study record(s)

Description of key information

Short description of key information on bioaccumulation potential result: 
It is the study of researches concerning to the transformation and of excretion from the organism of the nitroglycerine absorbed by inhalation or of absorbing by the skin

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

The elimination of NG from organism is ensured mainly by kidneys and by the respiratory tract. Only metabolites are expelled from the organism. Although no toxicokinetic data are available now, on the basis of studies by Di Carlo and others it has been well ascertained that the elimination of metabolites in urine and air breathed out is rapid and similar as to the quantities. After 4 hours from a single intragastric administration, circa 20% of NG dose were found in urine in form of the above mentioned metabolites, and circa 20% of NG dose were found in the air breathed out in form of carbon dioxide.

The lack of NG residues in excrements proves that the substance undergoes total metabolic transformation in the organism.