Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-240-8 | CAS number: 55-63-0
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
It is the study of researches concerning to the transformation and of excretion from the organism of the nitroglycerine absorbed by inhalation or of absorbing by the skin
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
The elimination of NG from organism is ensured mainly by kidneys and by the respiratory tract. Only metabolites are expelled from the organism. Although no toxicokinetic data are available now, on the basis of studies by Di Carlo and others it has been well ascertained that the elimination of metabolites in urine and air breathed out is rapid and similar as to the quantities. After 4 hours from a single intragastric administration, circa 20% of NG dose were found in urine in form of the above mentioned metabolites, and circa 20% of NG dose were found in the air breathed out in form of carbon dioxide.
The lack of NG residues in excrements proves that the substance undergoes total metabolic transformation in the organism.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
