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Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

The substance exhibits a LC50 for freshwater fish of 6.104 mg/L.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
6.104 mg/L

Additional information

The submission substance contains many constituents making the analytical monitoring very difficult for the purposes of environment and ecotoxicological testing.

One reliable study is available for the registered substance. The toxicity to freshwater fish was studied by following to OECD TG No. 203 nd OECD Guidance document No. 23 on aquatic toxicity testing of difficult substances and mixtures, under GLP. Fish (Danio rerio) were exposed to Water-accommodated fraction (WAF) of the substance at loading rates of 2.0, 2.8, 3.8, 5.3, 7.2 and 10 mg/L over a test period of 96 hours (semi-static test, daily renewal). The fraction of the multi-constituent substance present in test medium were monitored daily; for this purpose, all the chromatographic peaks areas were summed as surrogate of a concentration for the multi-constituent substance. The overall measured concentrations, as total peak area, deviated more than 20% of the initial measured concentrations.

However, test data obtained with WAF Methodology apply for the multi-constituent substance according to OECD Guidance No. 23. Such WAF data are recommanded when assessing the aquatic toxicity of multi-component substance for the purposes of GHS / CLP. The endpoints were based on loading rates. The 96h-LC50 was determined to 6.104 mg/L.