Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 213-030-6 | CAS number: 917-61-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1984-09-04 to 1984-09-25
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- non-GLP study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- OECD 1981
- Deviations:
- no
- Principles of method if other than guideline:
- NA
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium cyanate
- EC Number:
- 213-030-6
- EC Name:
- Sodium cyanate
- Cas Number:
- 917-61-3
- Molecular formula:
- CNO.Na
- IUPAC Name:
- sodium cyanate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: white Russian
- Details on test animals or tissues and environmental conditions:
- body weight: 2.4 - 2.75 kg
age: 6-7 months
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the untreated left eye served as negative control.
- Amount / concentration applied:
- 0.1 g test item was applied once in rabbit´s eye.
- Duration of treatment / exposure:
- The subsatnce was applied one to the rabbit's eye (without washing).
- Observation period (in vivo):
- Examinations: 1, 24, 48 and 72 hours after application and thereafter once per day.
The observation period was 21 days after application. - Number of animals or in vitro replicates:
- 3 ( female)
- Details on study design:
- NA
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Remarks:
- (opacity)
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- cornea opacity score
- Remarks:
- (opacity)
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- cornea opacity score
- Remarks:
- (opacity)
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- cornea opacity score
- Remarks:
- (opacity)
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.22
- Max. score:
- 4
- Irritation parameter:
- cornea opacity score
- Remarks:
- (extent of opacity area)
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- cornea opacity score
- Remarks:
- (extent of opacity area)
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.67
- Max. score:
- 2
- Reversibility:
- fully reversible within: 24 h
- Irritation parameter:
- cornea opacity score
- Remarks:
- (extent of opacity area)
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- cornea opacity score
- Remarks:
- (extent of opacity area)
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.44
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 2
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 2
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.22
- Max. score:
- 2
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 3
- Reversibility:
- fully reversible within: 3 days
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 3
- Reversibility:
- fully reversible within: 3 days
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0.67
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.11
- Max. score:
- 3
- Reversibility:
- fully reversible within: 3 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- Not indicated.
- Other effects:
- No other effects.
Any other information on results incl. tables
Additional results:
irriation parameter Basis Time point results Max. scroce Reversibility
conjunctivae score (secretion) animal #1 24/48/72 h 0.33 3 fully reversible within: 48 hours
conjunctivae score (secretion) animal #2 24/48/72 h 0 3
conjunctivae score (secretion) animal #3 24/48/72 h 0 3
conjunctivae score (secretion) mean 24/48/72 h 0.11 3 fully reversible within: 48 hours
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance Sodium cyanate revealed only very weak irritating effects to rabbit´s eye (mean 24/48/72 h scores: cornea score 0.22, iris score 0.22, conjunctivae score 1.11, chemosis score 0) wich were reversible within at least 3 days.
- Executive summary:
In a primary eye irritation study, 0.1 g of sodium cyanate (98 %) was instilled into the conjunctival sac of the right eye of 6-7 months old White Russian rabbits (3 females) for 72 h hours. Animals then were observed for 21 days. Irritation was scored by the method of Draize. The substance Sodium cyanate revealed only very weak irritating effects to rabbit´s eye (mean 24/48/72 h scores: cornea score 0.22, iris score 0.22, conjunctivae score 1.11, chemosis score 0) which were reversible within at least 3 days. None of the individual animals showed a mean score over 24/48/72 h treatment higher than the threshold values given in 67/548/EEC and Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
