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EC number: 213-030-6 | CAS number: 917-61-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1984-06-14 to 1984-07-13
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: References see below
- Deviations:
- not specified
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- not applicable
- Principles of method if other than guideline:
- Test is performed according to the following references:
- Bliss, C.J., The Statistics of Bioassay, Academic Press, New York, 1962
- Finney, D.J., Probit Analysis, 2nd Ed. Cambridge Univ. Press, Cambridge 1952
- Hunter, W.J., Link, W. and Recht, P., Intercomparison study on the determination of single administration toxicity in rats, Commission of the European Communities, Health and Safety Directorate, J. Assoc. Off. Anal. Chem. 62, 864 - 873, 1979
- Weber, E., Grundriß d. biol. Statistik, G. Fischer-Verlag, Stuttgart, 7. Auflage, 1972 - GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Sodium cyanate
- EC Number:
- 213-030-6
- EC Name:
- Sodium cyanate
- Cas Number:
- 917-61-3
- Molecular formula:
- CNO.Na
- IUPAC Name:
- sodium cyanate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - body weight: male 141 - 199 g; female 135 - 163 g
- age: male 57-59 days; female 63 - 72 days
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- not indicated
- Doses:
- 2.15 - 10.0 mL/kg (215 - 1000 mg/kg)
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- not indicated
- Statistics:
- NA
Results and discussion
- Preliminary study:
- NA
Effect levelsopen allclose all
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 681 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 312 - 1 487
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 582 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 366 - 926
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 215 mg/kg bw
- Based on:
- test mat.
- Mortality:
- At the dose of 215 mg/kg, the mortality rate was 0 % and at the dose of 1000 mg/kg, the mortality rate was 80 %.
- Clinical signs:
- other: The symptoms of poisoning were disorders of central nervous system and decrease of tonicity . Additional disorders: conical convulsions, tonic convulsions and loss of startle reflexes were showed.
- Gross pathology:
- not indicated
- Other findings:
- At macroscopic examination of dead animals was showed in female rats of the medium concentration the intestinal mucosa full with a red liquid.
Any other information on results incl. tables
no remarks
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50-values were 582 mg/kg bw (female, rat) and 681 mg/kg bw (male, rat).
- Executive summary:
In an acute oral toxicity study, groups of fasted 57-72 days old Wistar rats (3/sex) were given a single oral dose of sodium cyanate (98 %) in water by gavage at doses of 215 to 1000 mg/kg bw.
Oral LD50
Males = 681 mg/kg bw
Females = 582 mg/kg bw
LD0 (male/female) = 215 mg/kg bw
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