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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Currently viewing:

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Review article only. Read across to sodium cyanate. For justification of read across see endpoint summary.
Cross-reference
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
review article or handbook
Title:
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inorganic substances containing I-IV group elements)
Author:
Filov V.A.
Year:
1988
Bibliographic source:
Chimia, 1988, page 351

Materials and methods

Study type:
not specified
Endpoint addressed:
repeated dose toxicity: oral
Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Public available literature. No guideline indicated. For details on method see materials and methods section.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium cyanate
EC Number:
213-030-6
EC Name:
Sodium cyanate
Cas Number:
917-61-3
Molecular formula:
CNO.Na
IUPAC Name:
sodium cyanate

Method

Type of population:
not specified
Ethical approval:
not specified
Route of exposure:
other: unreported, most probably oral
Reason of exposure:
other: no data, most probably intentional
Exposure assessment:
not specified
Details on exposure:
duration of exposure: 26 weeks

Results and discussion

Clinical signs:
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
TDLo - Lowest published toxic dose = 5475 mg/kg/ 26 weeks equivalent to 30 mg/kg bw/day (intermittent)

Applicant's summary and conclusion

Conclusions:
TDLo - Lowest published toxic dose (human) = 5475 mg/kg/26 weeks equivalent to 25 mg/kg bw/day (intermittent)
Executive summary:

In a 26 weeks human study sodium cyanate was administered most probably oral.

Effects observed:

Sense Organs and Special Senses (Eye) - effect, not otherwise specified

TDLo - Lowest published toxic dose = 5475 mg/kg/26 weeks equivalent to 25 mg/kg bw/day (intermittent)

This study in humans is acceptable as supporting study.