Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
in vivo mammalian germ cell study: cytogenicity / chromosome aberration
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Untersuchung der cytogenetischen Wirkung einer Reihe einwertiger Alkohole auf die Zellen des Knochenmarks von Ratten
Author:
Bariljak, I.R., Kozachuk, S.Ju.
Year:
1988
Bibliographic source:
Citologija i Genetika 22(2), 49-52

Materials and methods

Principles of method if other than guideline:
no data
GLP compliance:
no
Type of assay:
chromosome aberration assay

Test material

Constituent 1
Chemical structure
Reference substance name:
Propan-1-ol
EC Number:
200-746-9
EC Name:
Propan-1-ol
Cas Number:
71-23-8
Molecular formula:
C3H8O
IUPAC Name:
propan-1-ol
Specific details on test material used for the study:
Analytical purity: no data

Test animals

Species:
rat
Strain:
not specified
Sex:
male

Administration / exposure

Route of administration:
other: no data
Duration of treatment / exposure:
48h
Doses / concentrations
Remarks:
Doses / Concentrations:
1/5 LD50
Basis:
no data

Results and discussion

Test results
Sex:
male
Genotoxicity:
other: inconclusive
Toxicity:
not specified
Vehicle controls validity:
not specified
Negative controls validity:
not specified
Positive controls validity:
not specified

Applicant's summary and conclusion