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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to guideline study with acceptable restrictions (occlusive exposure) study prior to GLP; peer reviewed study (EU RAR)

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Range finding toxicity data - List V -
Author:
Smyth H.F., Carpenter C.P., Weil C.S., Pozzani U.C
Year:
1954
Bibliographic source:
Arch. ind. hyg. occupat. med. 10, 61-68.
Reference Type:
secondary source
Title:
EU Risk Assessment Report, CAS No. 71-23-8: Propan-1-ol, Vol. 82
Author:
not applicable
Year:
2008
Bibliographic source:
ECB
Reference Type:
study report
Title:
Unnamed
Year:
1953
Report date:
1953

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
yes
Remarks:
(occlusive treatment, only 4 males/dose)
Principles of method if other than guideline:
Draize, J.H. et al., J. Pharmacol. Exp. Therap., 82, 377, (1944)

The fur is closely clipped over the entire trunk, and the dose, retained beneath an impervious plastic film, contacts about 1/10 of the body surface. Dosages greater than 20 ml/kg cannot be retained in contact with the skin. After 24 hours contact the film is removed, and mortality is considered complete after 14 additional days.
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Propan-1-ol
EC Number:
200-746-9
EC Name:
Propan-1-ol
Cas Number:
71-23-8
Molecular formula:
C3H8O
IUPAC Name:
propan-1-ol
Specific details on test material used for the study:
Analytical purity: no data

Test animals

Species:
rabbit
Strain:
other: New Zealand giant albino rabbits
Sex:
male
Details on test animals or test system and environmental conditions:
- Weight at study initiation: 2.5-3.5 kg

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
TEST SITE
- Area of exposure: 1/10 of body surface
- % coverage: no data
- Type of wrap if used: no data

REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data

TEST MATERIAL
- Amount(s) applied: maximal 20 ml/kg bw
- Concentration (if solution): undiluted



Duration of exposure:
24 h
Doses:
no data
No. of animals per sex per dose:
4 male animals
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
4 032 mg/kg bw
95% CL:
2 720 - 5 968
Remarks on result:
other: Conversion with density: 0.8 g/ml (original data given in publication: 5.04 ml/kg bw with 95 % confidence limits of 3.4-7.46)
Mortality:
no data
Clinical signs:
other: no data
Gross pathology:
no data

Applicant's summary and conclusion