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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Remarks:
(prior to GLP, only two doses tested, post exposure period 7 days)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
yes
Remarks:
(only two doses tested, study period only 7 days)
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Propan-1-ol
EC Number:
200-746-9
EC Name:
Propan-1-ol
Cas Number:
71-23-8
Molecular formula:
C3H8O
IUPAC Name:
propan-1-ol
Test material form:
liquid
Specific details on test material used for the study:
- Analytical purity: 99.5%

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
- Source: Gassner
- Mean body weight range at study initiation: 259-262g (male), 174-178g (female)

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 35%

MAXIMUM DOSE VOLUME APPLIED:
Doses:
8250 and 10000 µl/kg bw (approx 6,600 and 8000 mg/kg; conversion with density 0.8 g/cm3 (20°C))
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: animals were checked for mortality 1h after application (day 1), then on day 2, day 3 and day 7 of the study. Weighing was performed on day of application (day 1) then on day 4 and day 7. Clinical signs of toxicity were observed several times on day of application then on days 4, 5, 6 and 7
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 8 000 mg/kg bw
Mortality:
see table 1 below
Clinical signs:
other: DAY 1 (similar symptoms in both dose groups) - Immediately after application: irregular and intermittent breathing, apathy, abdominal and lateral position, atony, exsicosis - 1h after application: irregular and intermittent breathing, apathy, abdominal an
Gross pathology:
Animals that died (8250 and 10000 µl/kg bw)
- Heart (acute dilation, acute congestion), Stomach (redness), Intestine (hemorrhagic and diarrhetic contents)

Survivors (till day 7)
- No adverse gross pathological finding observed

Any other information on results incl. tables

Table 1: Mortality of Spraque-Dawley Rats after Single Oral Dosage (gavage) with Propan-1-ol

No. of animals

Death within

1h

24h

48h

7 days

6600 mg/kg bw

5 males

0/5

0/5

0/5

0/5

5 females

0/5

1/5

2/5

2/5

8000 mg/kg bw

5 males

0/5

3/5

3/5

3/5

5 females

0/5

1/5

1/5

1/5

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met