Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-403-1 | CAS number: 106-49-0
Monitoring data
Administrative data
- Endpoint:
- monitoring data
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given
Data source
Referenceopen allclose all
- Title:
- No information
- Author:
- Luceri F, Pieraccini G, Moneti G, Dolara P (1993). Primary aromatic amines from side-stream cigarette smoke are common contaminants of indoor air. Toxicol. Ind. Health 9 (3), 405-413.
- Reference Type:
- secondary source
- Title:
- p-Toluidine - CAS No: 106-49-0 - SIDS Initial Assessment Report.
- Author:
- OECD
- Year:
- 2 005
- Bibliographic source:
- UNEP Publications
Materials and methods
- Principles of method if other than guideline:
- GC/MS
- GLP compliance:
- not specified
- Type of measurement:
- concentration at contaminated site
- Media:
- other: tobacco smoke
Test material
- Reference substance name:
- p-toluidine
- EC Number:
- 203-403-1
- EC Name:
- p-toluidine
- Cas Number:
- 106-49-0
- Molecular formula:
- C7H9N
- IUPAC Name:
- 4-methylaniline
Constituent 1
Results and discussion
Any other information on results incl. tables
High levels of p-Toluidin were measured. Both the main stream smoke of cigarettes, (which is inhaled by the smoker) and the side stream smoke of cigarettes (which is also inhaled by the non smoker) contain significant amounts of all toluidine isomers and other aromatic amines. Depending on the brand, the p-toluidine content is 14-42 ng/cigarette in the main-stream smoke, and 10-100 times more in the side-stream smoke (562-2,390 ng/cigarette).
In
air, there are several aromatic amines (tracers of cigarette smoke). There
is a strong correlation of o-toluidine levels (ng/m3) in indoor air with
the smoking status of the inhabitants:
- Office of a non smoker with smokers in contiguous room 3.7
- Office of a non smoker with smokers in contiguous room after overnight ventilation
0.5
- Office with 1 smoker 2.9
- Office with 2 smokers 6.3
- Club room 11.3
- Non-smoking train compartment 1.1
- Hair-dresser saloon 4.8
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
