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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Effects on fertility

Effect on fertility: via oral route
Dose descriptor:
NOAEL
1 000 mg/kg bw/day
Additional information
The oral administration of Ammonium Zirconium Carbonate to rats for a period of up to forty five consecutive days at dose levels of up to 1000 mg/kg/day did not result in any toxicologically significant effects. Therefore, the “No Observable Effect Level” (NOEL) for animals of either sex was considered to be 1000 mg/kg/day for systemic toxicity. No treatment-related effects in the reproductive performance and offspring development up to day 4 of lactation were detected at dose levels of up to 1000 mg/kg/day. Therefore, the “No Observed Effect Level” (NOEL) was considered to be 1000 mg/kg/day for reproductive and developmental toxicity.

Short description of key information:
A GLP-compliant oral gavage combined repeat dose toxicity study with reproduction / developmental toxicity screening test in the rat has been conducted in accordance with OECD Guideline 422 (1996). No treatment-related effects were observed at dose levels up to and including 1000 mg/kg/day.

Effects on developmental toxicity

Description of key information
A GLP-compliant oral gavage combined repeat dose toxicity study with reproduction / developmental toxicity screening test in the rat has been conducted in accordance with OECD Guideline 422 (1996). No treatment-related effects were observed at dose levels up to and including 1000 mg/kg/day.
Effect on developmental toxicity: via oral route
Dose descriptor:
NOAEL
1 000 mg/kg bw/day
Additional information

Oral administration of Ammonium Zirconium Carbonate to rats for a period of up to forty-five consecutive days at dose levels of up to 1000 mg/kg/day did not result in any treatment-related effects in offspring up to day 4 of lactation.

Therefore, the “No Observed Effect Level” (NOEL) was considered to be 1000 mg/kg/day for developmental toxicity.

Justification for classification or non-classification

There were no treatment-related effects at dose levels of up and including 1000 mg/kg/day in a combined repeat dose toxicity study with reproduction / developmental toxicity screening test in the rat and there is no other data available suggesting that the substance has the potential to be a reproductive or developmental toxin. On this basis the substance is not classified for reproductive or developmental effects.

Additional information