Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-855-1 | CAS number: 75-26-3
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
For toxicity to reproduction, the most recent reliable studies were selected as the key study.
Short description of key information:
In a repeated-dose male reproductive toxicity study (NTP-CERHR, 2003 citing Wu, 1999), which was not conducted in accordance with an applicable OECD Guideline or GLP, several effects of subcutaneous injection of 2-bromopropane at increasing concentrations in mature and immature rats were observed at the lowest dose tested (200 mg/kg bw/day). Rats were dosed 5 days/week for 5 or 7 weeks. Adverse effects observed in male rats included dose-related reductions in sperm count and viability and increases in deformed sperm and testicular lesions.
Supporting studies documented dose-dependent reductions in spermatogonia numbers in male rats, depletion of ovarian follicle pools in female mice, amenorrhea in female rats and impaired development of reproductive organs of offspring at maternally toxic doses in the rat.
Effects on developmental toxicity
Additional information
Based upon the available studies for toxicity to reproduction in combination with the human exposure observations, 2-bromopropane should be classified as Reproductive Toxicant Category 1A: Known Human Reproductive Toxicant as described in EC No 1272/2008, and labeling as R60 (May Impair Fertility) and R61 (May Cause Harm to the Unborn Child) is appropriate.
Justification for classification or non-classification
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
