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Toxicity to microorganisms

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Description of key information

A study was carried out similar or equivalent to EU Method C.11 and OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test), specifically following the Umweltbundesamt (UBA) Guidelines: Bewertung wassergefahrdender Stoffe, III Bestimmung der akuten Bakterientoxizitat, Ad-hoc-Arbeidsgruppe I (Obmann Dr. Niemitz), LTwS, Nr. 10, September 1979. 
Nicotinamide was investigated for its ability to inhibit the cell multiplication of the bacteria species Pseudomonas putida. Cultures of Pseudomonas putida bacteria were exposed to concentrations ranging from 3.9 to 8000 mg Nicotinamide per liter. After incubation the extinction values of the bacterial cell suspensions were measured and a toxicity threshold value of Nicotinamide of 4235 mg/L for Pseudomonas putida was determined. The "Bewertungszahl" (Assessment figure or value for bacterial toxicity) is therefore 2.4 (Bewertung wassergefaehrdender Stoffe, 1979).

Key value for chemical safety assessment

EC10 or NOEC for microorganisms:
4 235 mg/L

Additional information