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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1996
Report date:
1996

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: 92/69/EEC, B1
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2,4-trimethyl-4-phenyl-butane-nitrile
EC Number:
422-580-8
EC Name:
2,2,4-trimethyl-4-phenyl-butane-nitrile
Cas Number:
75490-39-0
Molecular formula:
C13 H17 N
IUPAC Name:
2,2-dimethyl-4-phenylpentanenitrile

Test animals

Species:
other: Rat (Sprague-Dawley)

Administration / exposure

Vehicle:
other: Liquid substance administered neat, as supplied.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
1 693 mg/kg bw
95% CL:
1 437 - 1 994
Remarks on result:
other: Slope of the mortality curve: 12.13
Mortality:
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 3
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 4
Female: 1600 mg/kg bw; Number of animals: 5; Number of deaths: 2
Female: 1000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
other: Signs of toxicity related to dose levels: Mortality: Two females at 1600 mg/kg and three males and four females at 2000 mg/kg died during the study. Deaths occurred from within 4 hours of treatment until day 2. Clinical signs: Piloerection wa
Gross pathology:
Effects on organs:
Macroscopic examination of all decedents at 2000 mg/kg
revealed a darkened appearance of the liver.

No macroscopic abnormalities were observed in either the
decedents at 1600 mg/kg or in surviving animals.

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU