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EC number: 268-625-3 | CAS number: 68131-72-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Two skin sensitisation studies (Maximization test in guinea pigs) have been conducted on the substance. Both studies showed the substance to be non-sensitising to skin.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Two skin sensitisation studies (Arcelin G (2011) and Manciaux X (2002d)) were conducted (Maximisation method, OECD Guideline no.406) on the substance (Polyphosphoric acids, esters with triethanolamine, sodium salts). Both studies are considered to be of reliability 1 and are summarised below:
Arcelin G (2011) - Key Study
In order to assess the cutaneous allergenic potential of Polyphosphoric acids, esters with triethanolamine, sodium salts, the Maximization-Test was performed in 15 (10 test and 5 control) male albino Dunkin Hartley guinea pigs, in accordance with OECD Guideline No. 406 and the Commission Regulation (EC) No 440/2008, B.6.
The intradermal induction of sensitisation in the test group was performed in the nuchal region with a 10% dilution of the test item in purified water and in an emulsion of Freund's Complete Adjuvant (FCA)/physiological saline. The epidermal induction of sensitisation was conducted for 48 hours under occlusion with the test item at 100% (neat, applied as delivered) one week after the intradermal induction. The animals of the control group were intradermally induced with purified water and FCA/physiological saline,
Two weeks after epidermal induction the test and control animals were challenged by epidermal application of the test item at 75% in purified water and purified water alone under occlusive dressing.
Cutaneous reactions were evaluated at 24 and 48 hours after removal of the dressing.
No intercurrent deaths occurred during the course of the study.
No toxic signs were evident in the guinea pigs of the control or test group.
No local skin effects were observed in the guinea pigs of the control or test group.
Manciaux X (2002d) - Supporting study
The sensitisation potential of RHODAFAC BP10 was evaluated in female Hartley guinea pigs according to the maximisation method of Magnusson and Kligman, described in O.E.C.D. guideline Nb.406, and in compliance with Good Laboratory Practice.
Concentrations of the test substance to be used in the main study were determined in a preliminary assay with 2 animals. Ten test and five control animals were then included in the main assay. In the main assay, the induction treatment consisted of 3 pairs of intradermal injections (0.1 ml) on day 1in the scapular area of the back: the test article at 10% (w/w) in the mixture Freund's complete adjuvant/isotonic saline, the test item in the vehicle, or the Freund’s complete adjuvant at 50% (v/v). Control animals received intradermal injections of saline, Freund's Complete Adjuvant, and vehicle at 50% (w/v) in a mixture Freund's Complete Adjuvant/0.9% NaCl.
On day 7, the same region received a topical application of sodium lauryl sulfate in vaseline (10% w/w) in order to induce local irritation. On day 8, the test article, undiluted, (treated group) or the vehicle (control group) was applied topically to the test site, which was then covered by an occlusive dressing for 48 hours.
On day 22, the animals of treated and control groups were challenged by a topical occlusive application of the vehicle and the undiluted test article for 24 hours on one flank. The cutaneous reactions were evaluated 24 and 48 hours after patch removal.
No clinical signs and no deaths were noted during the study.
No cutaneous reactions were observed after the challenge application.
Under these experimental conditions,RHODAFAC BP10 does not induce sensitisation response in guinea pigs.
Migrated from Short description of key information:
Two skin sensitisation studies (Maximization test in guinea pigs) have been conducted on the substance. Both studies showed the substance to be non-sensitising to skin.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
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