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EC number: 906-170-0
CAS number: -
DBE has been tested for skin irritation on 3 New Zealand White rabbits
according to OECD guideline n° 404 and EU guideline n° B.4 (Draize
Method) in compliance with Good Laboratory Practice. The rabbits
received a dermal dose of 0.5 ml of DBE on a gauze on intact and abraded
skin sites under an semiocclusive dressing for a period of 24 hours.
Scores for erythema and oedema were measured 1, 24, 48 and 72 hours
after patch removal and primary cutaneous index was calculated (maximum
possible index =12)
No sign of dermal irritation (score = 0 for erythema and oedema) was
observed for intact skin site of the 3 rabbits at any reading time.
Primary Irritation Index was = 0.0. No other signs of intoxication were
Based on these results DBE is not classified irritating to skin
according to the criteria of the Directive 67/548/CEE and according to
EU Regulation 1272/2008 (CLP).
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