Registration Dossier
Registration Dossier
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EC number: 906-170-0 | CAS number: -
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The 72-hour EC50 (growth rate and yield) of DBE is estimated to be greater than 85 mg/l in the OECD 201 test.
Key value for chemical safety assessment
- EC10 or NOEC for freshwater algae:
- 36 mg/L
Additional information
One reliable key study is available for this endpoint. In this study (Weber B., 2010) the influence of the test item on the growth of the freshwater green algal speciesPseudokirchneriella subcapitata was investigated in a 72-hour static test according to OECD Guideline 201 (2006), the EU Commission Directive 92/69/EEC, C.3 (1992) and the Commission Regulation (EC) No 761/2009, C.3.
This study has been performed in compliance with the Swiss Ordinance relating to Good Laboratory Practice, adopted 2005 [SR 813.112.1]. This ordinance is based on the OECD Principles of Good Laboratory Practice, as revised in 1997 and adopted November 26th, 1997 by decision of the OECD Council [C(97) 186/Final]. Theses principles are compatible with Good Laboratory Practice regulations specified by regulatory authorities throughout the European Community, the EPA and FDS and MHLW, MAFF and METI.
The nominal concentrations of the test item of 4.6, 10, 22, 46 and 100 mg/L were tested in parallel with a control.
The measured concentrations of the test item in the test media of the nominal test concentrations of 46 and 100 mg/L were 99 and 100% of the nominal values, respectively, at the start of the test. During the test period of 72 hours, a decrease of test item concentration in the test media occurred. At the end of the test, 62 to 72% of the nominal values were found.
The mean measured concentrations (calculated as the geometric means of the concentrations measured at the start and the end of the test) in the test concentrations of 46 and 100 mg/L were 36 and 85 mg/L, respectively. The nominal test concentrations of 4.6 to 22 mg/L were not analyzed, since these concentrations were below the NOEC determined in this test.
The biological results (based on mean measured test item concentrations) were as follows:
Parameter |
Growth rate |
Yield |
(0-72 h) |
|
|
EC10 (mg/L) |
>85 |
73 |
95% confidence interval |
n.d. |
50 - 86 |
EC20 (mg/L) |
>85 |
>85 |
95% confidence interval |
n.d. |
n.d. |
EC50 (mg/L) |
>85 |
>85 |
95% confidence interval |
n.d. |
n.d. |
NOEC (mg/L) |
36 |
36 |
LOEC (mg/L) |
85 |
85 |
n.d. could not be determined
All the validity criteria were fulfilled.
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