Registration Dossier
Registration Dossier
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EC number: 203-404-7 | CAS number: 106-50-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: This study was a secondary study with very limited methodology and results reported.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 977
Materials and methods
- Principles of method if other than guideline:
- Rabbits were dermally exposed to the test substance in 10 mL of an oxidation-type hair dye base. Mortality was reported.
- GLP compliance:
- no
Test material
- Details on test material:
- Test substance: Oxidation type hair dye containing PPD
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: New Zealand
Administration / exposure
- Duration of exposure:
- 24 hours
- Doses:
- not reported
- No. of animals per sex per dose:
- Groups of 4 to 8 rabbits
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- other: mortality
- Effect level:
- 5 000 mg/kg bw
Applicant's summary and conclusion
- Executive summary:
Rabbits were dermally exposed to the test substance in 10 mL of an oxidation-type hair dye base. Mortality was observed at 5 g/kg.
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