Registration Dossier
Registration Dossier
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EC number: 201-247-9 | CAS number: 80-07-9
Sediment toxicity
Administrative data
Link to relevant study record(s)
Description of key information
The key study was the chronic 28-day spiked sediment toxicity test on Chironomus riparius (conducted in accordance with OECD Guideline 218), from which aNOEC of 11.8 mg/kg dw (based on both survival and emergence rate) was reported. The hazard assessment was based on the lower of two values, as determined from the chronic sediment assay and the predicted sediment toxicity as determined by the equilibrium partitioning method (EPM).
Key value for chemical safety assessment
- EC50 or LC50 for freshwater sediment:
- 40.5 mg/kg sediment dw
- EC10, LC10 or NOEC for freshwater sediment:
- 11.8 mg/kg sediment dw
Additional information
A chronic sediment toxicity assay of the substance on Chironomus riparius (Hicks, 2014) evaluated five endpoints (survival, emergence rate, and development rate in males, females and the the total population).
The key value was the reported NOEC of 11.8 mg/kg dw for
both the emergence rate and survival endpoints. The most sensitive endpoint was emergence rate, for which the study reported an EC50value of 40.5 mg/kg dw and an EC10value of 14.9 mg/kg dw(each determined from total radioactive residue, or TRR). The reported EC50 and EC10values based on motality were 47.6 mg/kg dw and 15.1 mg/kg dw, respectively (each determined from TRR).
The reported values for the development rate endpoints were notably higher.
The hazard assessment was based on the lower of two values, as determined from the chronic sediment assay (described above) and the predicted sediment toxicity, extrapolated from aquatic (pelagic) toxicity by the equilibrium partitioning method (ECB 2003).
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