Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
neurotoxicity, other
Remarks:
: in-vitro/in-vivo experiments
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Special investigation

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
2003

Materials and methods

Principles of method if other than guideline:
Phosphoryl trichloride (and phosphorus trichloride and thiophosphoryl trichloride) are highly toxic based on acute oral and inhalation data with rats. This study considers their mechanisms of toxicity.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Phosphoryl trichloride
EC Number:
233-046-7
EC Name:
Phosphoryl trichloride
Cas Number:
10025-87-3
Molecular formula:
Cl3OP
IUPAC Name:
phosphoroyl trichloride
Test material form:
liquid
Details on test material:
99% - from Aldrich Chemical (Milwaukee, WI)

Test animals

Species:
other: see exmainations
Strain:
other: see examinations

Administration / exposure

Route of administration:
other: see examinations
Vehicle:
other: see examinations
Duration of treatment / exposure:
see examinations
Frequency of treatment:
see examinations
No. of animals per sex per dose:
see examinations

Results and discussion

Results of examinations

Details on results:
Phosphoryl trichloride inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Phosphotrichlorides have high vapor toxicity to houseflies with in vivo inhibition of brain AChE activity correlating with mortality. Phosphoryl trichloride produces cholinergic poisoning signs on ip administration to mice, and give marked in vivo inhibition of serum BChE but not brain AChE activity. Activation of phosphoryl trichloride is confirmed by preparing pure phosphorodichloric acid and its potassium and dicyclohexylamine salts that reproduce the action of phosphoryl trichloride as in vitro AChE inhibitors and toxicants in mice.

Effect levels

Dose descriptor:
other: The mechanisms of toxicity were examined.
Remarks on result:
other: see 'Remarks'
Remarks:
Phosphoryl trichloride is highly toxic based on acute oral and inhalation data with rats. The mechanisms of toxicity were examined. Phosphoryl trichloride inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Phosphotrichlorides have high vapor toxicity to houseflies with in vivo inhibition of brain AChE activity correlating with mortality. Phosphoryl trichloride produces cholinergic poisoning signs on ip administration to mice, and give marked in vivo inhibition of serum BChE but not brain AChE activity. Activation of phosphoryl trichloride is confirmed by preparing pure phosphorodichloric acid and its potassium and dicyclohexylamine salts that reproduce the action of phosphoryl trichloride as in vitro AChE inhibitors and toxicants in mice.

Applicant's summary and conclusion

Executive summary:

Phosphoryl trichloride is highly toxic based on acute oral and inhalation data with rats. The mechanisms of toxicity were examined.

Phosphoryl trichloride inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Phosphotrichlorides have high vapor toxicity to houseflies with in vivo inhibition of brain AChE activity correlating with mortality. Phosphoryl trichloride produces cholinergic poisoning signs on ip administration to mice, and give marked in vivo inhibition of serum BChE but not brain AChE activity. Activation of phosphoryl trichloride is confirmed by preparing pure phosphorodichloric acid and its potassium and dicyclohexylamine salts that reproduce the action of phosphoryl trichloride as in vitro AChE inhibitors and toxicants in mice.