Registration Dossier
Registration Dossier
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EC number: 233-237-5 | CAS number: 10099-58-8
Endpoint summary
Administrative data
Description of key information
Oral: NOAEL (rat) ≥ 738 mg/kg bw/d
Key value for chemical safety assessment
Additional information
There is no study available for Lanthanum chloride. However, there is a reliable study available for the analogue substance, Lanthanum carbonate octahydrate, which after oral ingestion is converted to Lanthanum chloride in the acidic environment of the stomach.Thus, read-across was performed.
Oral
Repeated dose toxicity was analysed in a reliable subchronic feeding study with Lanthanum carbonate octahydrate performed under GLP according to OECD guideline 408. Groups of five male and female Wistar rats received nominal doses of 1400, 2400 and 14000 ppm for 90 days in the diet. In addition to the guideline protocol neurobehavioral tests as well as immunotoxicological examinations were performed in satellite groups. With the exception of single incidental findings no treatment- related adverse effects were detected. Therefore, the NOAEL was found to be 14000 ppm Lanthanum carbonate octahydrate corresponding to 10605 ppm Lanthanum chloride, anhydrous. Based on the daily food consumption the NOAEL is ≥ 738 mg/kg bw/d for males and ≥ 1122 mg/kg bw/d females, respectively, i.e. greater than the highest dose tested in the study.
Justification for classification or non-classification
There is conclusive data available which is not sufficient for classification.
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