Registration Dossier
Registration Dossier
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EC number: 484-470-6 | CAS number: 623-40-5
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study completed under GLP
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
- Test temperature:
- 35 +- 1°C
- Details on study design: HPLC method:
- Instrument: Alliance Separation Module 2695 (Waters, Milford, MA, USA) Detector: Dual lambda Absorbance Detector 2487 (Waters) Column: 150 mm x 4.6 mm id. Hypersil BDS-CN; dp = 5 microm (Thermo, San Jose, CA, USA) Column temperature: 35 +- 1 °C Mobile phase neutral pH: 30/70 (v/v) methanol/water Flow: 1 ml/min Injection volume: 10 microL UV detection: 210 nm
- Analytical monitoring:
- yes
- Type:
- Koc
- Value:
- < 20.9 dimensionless
- Temp.:
- 35 °C
- Type:
- log Koc
- Value:
- < 1.32 dimensionless
- Temp.:
- 35 °C
- Validity criteria fulfilled:
- not specified
- Conclusions:
- log Koc of the test substance was < 1.32 (Koc < 20.9)
- Executive summary:
The log Koc of MPKO was determined by means of HPLC. In the chromatogram of the test solution, one test substance peak was observed at a retention time of 2.6 minutes. Under the same analytical conditions, the retention time of phenol (log Koc = 1.32) was 3.1 minutes. Hence, it was concluded that the log Koc of the test substance was < 1.32 (Koc < 20.9)
Reference
Description of key information
Key value for chemical safety assessment
- Koc at 20 °C:
- 20.9
Additional information
One study investigating the adsorption of 2-Pentanone oxime was available. The adsorption coefficient was determined in a GLP-study according to OECD guideline 121 using HPLC. The determined log Koc was < 1.32 (KOC: < 20.9).
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