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EC number: 282-015-4
CAS number: 84082-70-2
Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Mentha piperita, Labiatae.
This in vitro study was performed
according to OECD Guideline 437 (2009) to assess the corneal irritation
and damage potential of Cornmint oil (mentha arvensis) by means of the
Bovine Corneal Opacity and Permeability Assay (BCOP) using fresh
isolated bovine corneae. The negative control responses of the opacity
and permeability values were less than the upper limits of the
laboratory historical range indicating that the negative control did not
induce irritancy on the corneas. The mean in vitro irritancy score of
the positive control (10% (w/v) Benzalkonium Chloride) was 119 and was
within the historical positive control data range. It was therefore
concluded that the test conditions were adequate and that the test
system functioned properly. Cornmint oil (mentha arvensis) did not
induce ocular irritation through both endpoints, opacity and
permeability, resulting in a mean in vitro irritancy score of 4.3 after
10 minutes of treatment. Finally, it is concluded that this test is
valid and that Cornmint oil (mentha arvensis) is not severe irritant or
corrosive in the BCOP test under the experimental conditions described
in the report.
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