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EC number: 282-015-4
CAS number: 84082-70-2
Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Mentha piperita, Labiatae.
Result expressed as overall irritation score for each animal as
reported in the study:
Total irritation score per group
Peppermint Flavour - Brazilian
* rabbit 291 killed at 24h due to broken back
A study was
conducted to investigate the irritation effects of Peppermint Flavour -
Brazilian when applied once to intact skin under a semi-occlusive
4-hour semi-occlusive patch test was conducted on 8 New Zealand white
rabbits. The test material and 2 control substances (Diethyl Phthalate
and Geraniol), were applied undiluted to the clipped dorsum of the 8
rabbits. Reaction grades for erythema, oedema, cracking and scaling were
assessed 4, 24, 48, and 72 hours after treatment by using grades ranging
from "a"(very slight) to "h"(severe). An overall irritation score was
assigned to each tested substance ranging from 0 (normal skin) to 7
(extreme). Peppermint Flavour - Brazilian showed mainly slight/moderate
effects with one site showing pale brown tissue 24 and 72 hours after
treatment. This response is similar to the control Geraniol. However
Geraniol showed no evidence of necrosis. In order to classify the test
substance in accordance with EU classification, the irritation scoring
from "a" to "h" as reported in this study, is converted to the grading
of skin reactions as defined by OECD Guideline 404. The mean scores
calculated from the numerical values given to the skin irritation
observed at the 24, 48, and 72 hour examinations were 1.6, 1.6, and 1.8
resp. for erythema, and also for oedema. Based on these conversed scores
and according to EU criteria Peppermint Flavour - Brazilian was
considered not irritating and the test substance does not have to be
classified according to the classification criteria outlined in
67/548/EEC and 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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