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Diss Factsheets
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EC number: 201-286-1 | CAS number: 80-51-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Remarks:
- in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- The prediction was based on dataset comprised from the following descriptors: "A B C" Estimation method: Takes highest mode value from the 5 nearest neighbours Domain logical expression:Result: In Domain ("a" and ("b" and "c" ) ) Domain logical expression index: "a" Referential boundary: The target chemical should be classified as SN1 AND SN1 >> Carbenium Ion Formation AND SN1 >> Carbenium Ion Formation >> Hydrazine by DNA binding by OECD Domain logical expression index: "b" Parametric boundary:The target chemical should have a value of log Kow which is >= -1.58 Domain logical expression index: "c" Parametric boundary:The target chemical should have a value of log Kow which is <= 0.797
Data source
Reference
- Reference Type:
- other: Read across
- Title:
- 02.05.2013 09:28 [R]: Positive; Estimation for A B C for CAS 80-51-3
- Author:
- Keyser, D., E. Schelede (eds.)
- Year:
- 2 001
- Bibliographic source:
- Medizin&Wissen Verlagges, Munchen, ISBN 3-86094-163-1
Materials and methods
Test guideline
- Guideline:
- other: REACH Guidance on QSARs R.6 - Read across using the OECD QSAR Toolbox V3.1
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Test material form:
- not specified
- Details on test material:
- SMILES:c1(S(=O)(=O)NN)ccc(Oc2ccc(S(=O)(=O)NN)cc2)cc1
Constituent 1
- Specific details on test material used for the study:
- c1(S(=O)(=O)NN)ccc(Oc2ccc(S(=O)(=O)NN)cc2)cc1
In chemico test system
- Details on the study design:
- see attached report
Results and discussion
In vitro / in chemico
Results
- Remarks on result:
- other: QSAR prediction result
In vivo (non-LLNA)
Results
- Remarks on result:
- other: QSAR prediction result
In vivo (LLNA)
Results
- Remarks on result:
- other: QSAR prediction result
Any other information on results incl. tables
The
prediction was based on dataset comprised from the following
descriptors: "A B C"
Estimation method: Takes highest mode value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
("a"
and ("b"
and "c" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as SN1 AND SN1 >> Carbenium Ion
Formation AND SN1 >> Carbenium Ion Formation >> Hydrazine by DNA binding
by OECD
Domain
logical expression index: "b"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= -1.58
Domain
logical expression index: "c"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 0.797
The Toolbox made read-across from phenylhydrazine CAS 100 -63 -0 and from mercapto-acetic acid hydrazide CAS 760 -30 -5 both of which were considered as skinsenstisers and predicted OBSH to be positive for skin sensitisation.
This can supported by the fact that OBSH by hydrolysis generate hydrazine which is CLH-classified as Skin sens. 1.
Applicant's summary and conclusion
- Interpretation of results:
- other: Positive
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Test substance is a skin sensitizer based on OECD-toolbox prediction and read-across
- Executive summary:
OECD QSAR Toolbox V3.1 has been used and read across results showed that the substance is a skin sensitizer.
The Toolbox made read-across from phenylhydrazine CAS 100 -63 -0 and from mercapto-acetic acid hydrazide CAS 760 -30 -5 both of which were considered as skinsenstisers and predicted OBSH to be positive for skin sensitisation.
This can be supported by the fact that OBSH by hydrolysis generate hydrazine which is CLH-classified as Skin sens. 1.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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