Registration Dossier
Registration Dossier
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EC number: 222-429-4 | CAS number: 3468-63-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Purity unknown, limited description of the method, test period unknown
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Guideline:
- other: Barail test with intracutaneous injection
- GLP compliance:
- no
Test material
- Reference substance name:
- 1-[(2,4-dinitrophenyl)azo]-2-naphthol
- EC Number:
- 222-429-4
- EC Name:
- 1-[(2,4-dinitrophenyl)azo]-2-naphthol
- Cas Number:
- 3468-63-1
- Molecular formula:
- C16H10N4O5
- IUPAC Name:
- 1-[(2,4-dinitrophenyl)diazenyl]-2-naphthol
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Gelb-Silber
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- other: Sesame oil
- Duration of treatment / exposure:
- Daily exposures over five days of 0.5mL of 5 or 10% C.I. Pigment Orange 5 in sesame oil to clipped rapid skin.
- Observation period:
- 5 days
- Number of animals:
- 6
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 5 days
- Score:
- ca. 0
- Remarks on result:
- other: Daily exposures over five days with 0.5mL of 5 or 10% of C.I. Pigment Orange 5 in sesame oil to clipped rabbit skin didn’t show any skin reactions.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Daily exposures over five days with 0.5mL of 5 or 10% of C.I. Pigment Orange 5 in sesame oil to clipped rabbit skin didn’t show any skin reactions.
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