1-[(2,4-dinitrophenyl)azo]-2-naphthol

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

publication

Title:

Investigations on the disposition of oral doses of some water insoluble pigments.

Author:

El Darer, S.M., Tillery, KF., and Hill, D.L.

Year:

1984

Bibliographic source:

Bull. Environ. Contam. Toxicol. 32, 171-174.

Materials and methods

Test material

Test material information

Constituent 1

Reference substance name:

1-(4-methyl-2-nitrophenylazo)-2-naphthol

EC Number:

219-372-2

EC Name:

1-(4-methyl-2-nitrophenylazo)-2-naphthol

Cas Number:

2425-85-6

Molecular formula:

C17H13N3O3

IUPAC Name:

1-[(4-methyl-2-nitrophenyl)diazenyl]-2-naphthol

Test animals

Species:

rat

Strain:

Fischer 344

Sex:

male

Administration / exposure

Route of administration:

oral: feed

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information): low bioaccumulation potential based on study results
The absorption of CI Pigment Red 3 (purity, 94.7 %) was studied in male Fischer 344 rats, seven to eight weeks of age, given the compound once at 11.8 mg/kg bw suspended in corn oil by gavage. Gut contents, faeces and various tissues were extracted 1, 4, 24 and 48 h after dosing and the amount of parent compound present was determined. None was found in blood, liver or kidneys, and it was concluded that the compound is not absorbed from the intestinal tract. Recovery after 48 h was 72.4% of the dose, suggesting that the compound may be partly degraded by intestinal bacteria. (The Working Group noted that absorption of cleavage products or metabolites was not analysed.)