Registration Dossier
Registration Dossier
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EC number: 203-401-0 | CAS number: 106-47-8
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original reference not translated
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Studies on sulfhemoglobin formation by various drugs
- Author:
- Nomura A
- Year:
- 1 975
- Bibliographic source:
- Folia Pharmacol Japon 71: 351-365
- Reference Type:
- review article or handbook
- Title:
- p-Chloraniline BUA-Stoffbericht No 153
- Author:
- BUA (Beratergremium umweltrelevanter Altstoffe) (BUA)
- Year:
- 1 996
- Bibliographic source:
- Gesellschaft Deutscher Chemiker (Hrsg Behret), VCH (Verlag Chemie), Weinheim
- Reference Type:
- review article or handbook
- Title:
- 4-CHLOROANILINE
- Author:
- IPCS-INCHEM
- Year:
- 2 003
- Bibliographic source:
- in: Concise International Chemical Assessment Document 48
Materials and methods
- Principles of method if other than guideline:
- Endpoint was created to support overall results.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-chloroaniline
- EC Number:
- 203-401-0
- EC Name:
- 4-chloroaniline
- Cas Number:
- 106-47-8
- Molecular formula:
- C6H6ClN
- IUPAC Name:
- 4-chloroaniline
Constituent 1
Administration / exposure
- Route of administration:
- intraperitoneal
- Doses:
- 64 mg/kg bw
Results and discussion
- Clinical signs:
- Very high methaemoglonin formation (60 -70% methaemoglobin) occurs as early as 10 min after intraperitoneal application.
Any other information on results incl. tables
p-chloroaniline is a potent methaemoglobin inducer, as demonstrated in mice, rats, and cats. Very high methaemoglonin formation (60 -70% methaemoglobin) occurs as early as 10 min after intraperitoneal application.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
