Registration Dossier
Registration Dossier
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EC number: 203-401-0 | CAS number: 106-47-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given (No data on mortality, no data on clinical signs, no necropsy and no histopathological examinations were performed/reported)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data List VI
- Author:
- Smyth HF JR, Carpenter CP, Weil CS, Pozzani UC, Striegel JA
- Year:
- 1 962
- Bibliographic source:
- Am Ind Hyg Ass J 23: 95-107
- Reference Type:
- publication
- Title:
- p-chloroaniline, BUA-Stoffbericht 153
- Author:
- BUA
- Bibliographic source:
- Beratergremium für umweltrelevante Altstoffe (BUA) der Gesellschaft Deutscher Chemiker, 1995
Materials and methods
- Principles of method if other than guideline:
- according to Draize et al., J.Pharmacol.Exper.Therap. 82, 377 (1944)
- GLP compliance:
- no
- Remarks:
- GLP was not mandatory at the time of the study
Test material
- Reference substance name:
- o-toluidine
- EC Number:
- 202-429-0
- EC Name:
- o-toluidine
- Cas Number:
- 95-53-4
- IUPAC Name:
- o-toluidine
- Reference substance name:
- 4-chloroaniline
- EC Number:
- 203-401-0
- EC Name:
- 4-chloroaniline
- Cas Number:
- 106-47-8
- Molecular formula:
- C6H6ClN
- IUPAC Name:
- 4-chloroaniline
- Details on test material:
- - Name of test material (as cited in study report): p-chloroaniline
- Physical state: liquid
- Analytical purity: no data
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- -Type of wrap: plastic film
- Duration of exposure:
- 24 h
- Doses:
- No data on the doses employed were given in the publication. However, the publication stated that doses above 20 ml/kg could not be retained in contact with the skin of the animals
- No. of animals per sex per dose:
- 4
- Control animals:
- no
- Details on study design:
- Penetration of rabbit skin was estimated by a technique closely alike to the one-day cuff method of Draize and associates. Before application, the fur was clipped from the entire trunk of the animals and the substance applied under a plastic film for 24h within which time the animals were immobilized (type of wrap: occlusive). The film was removed at the end of the application period and the animals were subsequently caged and observed for another 14d. LD 50 and its fiducial range were estimated by the method of Thompson (Use of Moving averages and interpolation to Estimate Median Effective Dose. Bacteriol. Rev. 1 115 (June 1947) using the tables of Weils (Tables for Convenient Calculation of Median-Effective Dose (LD50 or ED 50) and Instructions in Their Use. Biometrics 8: 249 (Sept. 1952)
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 360 mg/kg bw
- Mortality:
- No data on mortality
- Clinical signs:
- other: no data on clinical symptoms
- Gross pathology:
- No data on necropsy
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
