Registration Dossier

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

Mead and McKenzie (2005, reliability 1) have carried out a GLP study to assess the toxicity to algae (Scenedesmus subspicatus) of diammonium dithiodiglycolate which is the main thioglycolic acid degradation product.  Following preliminary testing, the main test was carried out as a limit test at 100 mg/L for a period of 72 hours. EC50 values have been determined to be > 100 mg/L and correspondingly the No Observed Effect Concentration was fixed at 100 mg/L.

Key value for chemical safety assessment

EC50 for freshwater algae:
100 mg/L
EC10 or NOEC for freshwater algae:
100 mg/L

Additional information

No valid studies were carried out for thioglycolic acid. Mead and McKenzie (2005, reliability 1) have carried out a GLP study to assess the toxicity to algae (Scenedesmus subspicatus) of diammonium dithiodiglycolate which is the main thioglycolic acid degradation product. This information is a good surrogate as half-life of thioglycolic acid in water is short as demonstrated by practical case (Devaux, 2003).

Following preliminary testing, the main test was carried out as a limit test at 100 mg/L for a period of 72 hours. EC50 values have been determined to be > 100 mg/L and correspondingly the No Observed Effect Concentration was fixed at 100 mg/L.