Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary literature

Data source

Reference
Reference Type:
review article or handbook
Title:
SIDS INITIAL ASSESSMENT REPORT - Cyanoacetates
Author:
OECD
Year:
2006

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Qualifier:
according to guideline
Guideline:
EU Method B.3 (Acute Toxicity (Dermal))
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethyl cyanoacetate
EC Number:
203-309-0
EC Name:
Ethyl cyanoacetate
Cas Number:
105-56-6
Molecular formula:
C5H7NO2
IUPAC Name:
ethyl 2-cyanoacetate

Results and discussion

Effect levelsopen allclose all
Dose descriptor:
LD50
Effect level:
> 1 000 mg/kg bw
Remarks on result:
other: in rabbits
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Remarks on result:
other: in rats
Clinical signs:
in rabbits: local skin irritation
in rats: no treatment-related findings reported

Applicant's summary and conclusion