Registration Dossier

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
study with acceptable restrictions (inhalation risk test) Ethyl cyanoacetic acid is an ester of cyanoacetic acid. It hydrolyzes rapidly under neutral and alkaline conditions to cyanoacetic acid and ethanol. It ca be assumed that for most endpoints cyanoacetic acid will be the common metabolite that determines the toxicity of both substances.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report date:
1980

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Smyth et al., Am. Ind. Hyg. Ass. J., (23) 1962
Principles of method if other than guideline:
Method:
The study intends to demonstrate the toxicity of an atmosphere saturated with vapors of the volatile components of a test substance.
GLP compliance:
no
Test type:
other: inhalation risk test

Test material

Constituent 1
Reference substance name:
Reference substance 001
Details on test material:
- Name of test material (as cited in study report): Cyanoessigsäure
- Physical state: liquid

Test animals

Species:
rat

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
nose only
Vehicle:
air
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- System of generating vapour: 200 l air are led through a 5 cm layer of the test substance. The temperature is 20 °C. The applied pressure is 766-772 mbar.
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
ca. 7 h
Concentrations:
0.92 mg/l (199.08 ppm)
No. of animals per sex per dose:
6
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations: daily up to 3 days post exposure
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Mortality:
No mortality
Clinical signs:
other: During 7 h exposure: irritation of mucosa, accelerated and intermittent respiration, lacrimation, eyelid closure
Gross pathology:
No treatment related abnormalities were observed.

Applicant's summary and conclusion